Helicobacter mustelae-associated gastric adenocarcinoma in ferrets (Mustela putorius furo)

Vet Pathol. 1997 May;34(3):225-9. doi: 10.1177/030098589703400308.


Helicobacter pylori in humans is associated with active, chronic gastritis, peptic ulcer disease, and most recently has been linked epidemiologically to gastric adenocarcinoma. A related organism, Helicobacter mustelae, naturally infects ferrets and also causes a persistent gastritis, a precancerous lesion, and focal glandular atrophy of the proximal antrum. In this report, we document the clinical presentation and histopathologic confirmation of H. mustelae-associated gastric adenocarcinoma in two middle-aged male ferrets. The ferret appears to be well suited to study the pathogenesis of naturally occurring Helicobacter sp.-induced gastric adenocarcinoma.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / microbiology
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / veterinary*
  • Animals
  • Ferrets*
  • Helicobacter / isolation & purification*
  • Helicobacter Infections / pathology*
  • Helicobacter Infections / veterinary*
  • Male
  • Stomach Neoplasms / microbiology
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / veterinary*