Defining a role for c-Myc in breast tumorigenesis

Breast Cancer Res Treat. 1997 May;44(1):1-22. doi: 10.1023/a:1005858611585.

Abstract

The proto-oncogene c-myc is commonly amplified and overexpressed in human breast tumors, and the tumorigenic potential of c-myc overexpression in mammary tissue has been confirmed by both in vitro and in vivo models of breast cancer. However, the mechanisms by which Myc promotes tumorigenesis are not well understood. Recent evidence indicates that Myc can promote cell proliferation as well as cell death via apoptosis. These studies provide new insight and impetus in defining a role for c-Myc in breast tumorigenesis and may point toward novel targets for breast cancer therapy.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Apoptosis / genetics
  • Apoptosis / physiology
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology*
  • Cell Cycle / genetics
  • Cell Cycle / physiology
  • Female
  • Gene Expression Regulation, Neoplastic / genetics
  • Gene Expression Regulation, Neoplastic / physiology
  • Humans
  • Proto-Oncogene Proteins c-myc / physiology*

Substances

  • Proto-Oncogene Proteins c-myc