Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins

Can J Physiol Pharmacol. 1997 Mar;75(3):205-7.


Citrulline malate is known to improve performance in weakened muscles. The present experiment was designed to test the hypothesis that citrulline malate can limit the effect of endotoxins on muscle fatigability. Endotoxemia was induced in rats by injection of lipopolysaccharides from Klebsiella pneumoniae. Resistance to fatigue was quantified by measuring tension production during repetitive electrical stimulation of the isolated epitrochlearis muscle. Oral treatment by citrulline malate was found to increase resistance to fatigue in infected rats, whereas twitch tension was not modified. This demonstrates the efficacy of citrulline malate for limiting an increase in muscle fatigue elicited with bacterial endotoxins.

MeSH terms

  • Animals
  • Citrulline / analogs & derivatives*
  • Citrulline / pharmacology
  • In Vitro Techniques
  • Klebsiella pneumoniae
  • Lipopolysaccharides / toxicity
  • Malates / pharmacology*
  • Male
  • Muscle Fatigue / drug effects*
  • Muscle Fatigue / physiology
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / physiology
  • Rats
  • Rats, Wistar


  • Lipopolysaccharides
  • Malates
  • Citrulline
  • citrulline malate