Neurohormonal response to head-up tilt and its role in vasovagal syncope

Am J Cardiol. 1997 May 1;79(9):1302-6. doi: 10.1016/s0002-9149(9x)00084-9.


In a controlled study, 26 patients with a history of recurrent syncope were found to have increased arginine vasopressin, corticotrophin, and atrial natriuretic factor levels after 5 minutes of 60 degrees head-up tilt, long before they became hypotensive. The exaggerated neurohormonal response in these patients may indicate a greater sensitivity to central hypovolemia which may predispose to vasovagal syncope, mediated by the vasodilatory effects of atrial natriuretic factor or the sensitization of mechanoreceptors by arginine vasopressin.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenocorticotropic Hormone / blood
  • Analysis of Variance
  • Arginine Vasopressin / blood
  • Body Surface Area
  • Forearm / blood supply
  • Hemodynamics / physiology
  • Hormones / blood*
  • Humans
  • Middle Aged
  • Posture / physiology*
  • Regional Blood Flow / physiology
  • Syncope, Vasovagal / physiopathology*
  • Tilt-Table Test


  • Hormones
  • Arginine Vasopressin
  • Adrenocorticotropic Hormone