Effects of Poncirus trifoliata on type I hypersensitivity reaction

Am J Chin Med. 1997;25(1):51-6. doi: 10.1142/S0192415X97000081.

Abstract

A study was carried out to examine the effect of an aqueous extract from immature fruit of Poncirus trifoliata L. (Rutaceae) (PTIFE) on the type I hypersensitivity reaction. Forty-eight hour PCA (passive cutaneous anaphylaxis) in rats was significantly inhibited by the oral administration of PTIFE (200 mg/kg). It also inhibited histamine release from rat peritoneal mast cells (RPMC) induced by mouse anti-dinitrophenyl (DNP)-IgE and dinitrophenyl-human serum albumin (DNP-HSA). These results suggest that PTIFE has anti-allergic action against the type I hypersensitivity reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Antibodies / administration & dosage
  • Antigens / immunology
  • Antigens / toxicity
  • Dinitrophenols / toxicity
  • Disease Models, Animal
  • Fruit / chemistry
  • Fungicides, Industrial / toxicity
  • Histamine Release / drug effects
  • Humans
  • Hypersensitivity, Immediate / drug therapy*
  • Immunoglobulin E / immunology
  • Injections, Intradermal
  • Male
  • Mast Cells / drug effects
  • Mast Cells / metabolism
  • Mice
  • Passive Cutaneous Anaphylaxis / drug effects*
  • Peritoneum / cytology
  • Peritoneum / drug effects
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Serum Albumin / immunology
  • Specific Pathogen-Free Organisms

Substances

  • Antibodies
  • Antigens
  • Dinitrophenols
  • Fungicides, Industrial
  • Plant Extracts
  • Serum Albumin
  • Immunoglobulin E