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Clinical Trial
. 1997 Jun;154(6):870-2.
doi: 10.1176/ajp.154.6.870.

Sleep Deprivation Combined With Consecutive Sleep Phase Advance as a Fast-Acting Therapy in Depression: An Open Pilot Trial in Medicated and Unmedicated Patients

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Clinical Trial

Sleep Deprivation Combined With Consecutive Sleep Phase Advance as a Fast-Acting Therapy in Depression: An Open Pilot Trial in Medicated and Unmedicated Patients

M Berger et al. Am J Psychiatry. .

Abstract

Objective: The authors' goal was to test the hypothesis that the antidepressant effect of total sleep deprivation can be maintained by initially avoiding sleep during a supposedly "critical" time period in the early morning.

Method: They studied 33 inpatients with major depression, melancholic type, all of whom responded positively to total sleep deprivation. Twelve of the patients were men and 21 were women; their mean age was 46.7 years (SD = 13.7). After total sleep deprivation, the patients started a sleep schedule from 5:00 p.m. to 12:00 midnight, which then was shifted back by 1 hour each day until a sleep time of 11:00 p.m. to 6:00 a.m. was reached.

Results: Twenty (61%) of the 33 patients who responded to total sleep deprivation with an improved state of mood maintained this improvement during sleep phase advance therapy. Drug-free and medicated patients did not differ from each other.

Conclusions: The rapid amelioration of mood observed with total sleep deprivation can be preserved with a succeeding phase shift of the sleep period.

Comment in

  • Sustaining the effect of sleep deprivation.
    Smeraldi E, Benedetti F, Campori E. Smeraldi E, et al. Am J Psychiatry. 1998 Aug;155(8):1134-5. doi: 10.1176/ajp.155.8.1134. Am J Psychiatry. 1998. PMID: 9699713 No abstract available.

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