Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

Nature. 1997 May 29;387(6632):512-6. doi: 10.1038/387512a0.


The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / metabolism
  • Cell Adhesion
  • Dimerization
  • Epidermal Growth Factor / metabolism*
  • ErbB Receptors / metabolism*
  • Glycoproteins / metabolism*
  • Humans
  • Ligands
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Myocardium / metabolism
  • Nerve Growth Factors / metabolism*
  • Neuregulins
  • Phosphorylation
  • Proto-Oncogene Proteins / metabolism*
  • Receptor, ErbB-3
  • Receptor, ErbB-4
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • Sequence Homology, Amino Acid
  • Tumor Cells, Cultured
  • Tyrosine / metabolism


  • Glycoproteins
  • Ligands
  • Nerve Growth Factors
  • Neuregulins
  • Proto-Oncogene Proteins
  • Recombinant Proteins
  • Tyrosine
  • Epidermal Growth Factor
  • ERBB4 protein, human
  • ErbB Receptors
  • Erbb4 protein, mouse
  • Receptor, ErbB-3
  • Receptor, ErbB-4