Calcium and chemotropic turning of nerve growth cones

Perspect Dev Neurobiol. 1996;4(2-3):205-13.


Cultured Xenopus spinal neurons exhibit chemotropic turning toward the source of neurotransmitters acetylcholine and glutamate. Here we review the experimental evidence that transmitter-induced turning of the growth cone is mediated by an influx of Ca2+, that a gradient of intracellular Ca2+ within the growth cone is responsible for the directional growth cone response, and that asymmetric filopodia formation precedes and is essential for the turning response.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Calcium / physiology*
  • Chemotaxis*
  • Humans
  • Neurotransmitter Agents / physiology
  • Second Messenger Systems


  • Neurotransmitter Agents
  • Calcium