Abstract
In a 39-year-old patient under follow-up for metastatic adenocarcinoma of the colon, a post-operative fever and a profound neutropenia occurred during hospitalization. A diagnosis of primary infection with parvovirus B-19 was made in view of the association of reticulocytopenia, together with anti-B19 IgM antibodies and positive serum results for viral DNA. The granulocytic lineage appeared to be normal on bone-marrow smears, and anti PMN autoantibodies were not found. Rh G-CSF therapy resulted in a sharp increase in the PMN count. Although the pathophysiology of B19-associated neutropenia remains unclear, Rh G-CSF seems to be effective in this disorder.
MeSH terms
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Adenocarcinoma / complications
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Adenocarcinoma / secondary
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Adenocarcinoma / surgery
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Adult
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Amikacin / administration & dosage
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Amikacin / therapeutic use
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Colonic Neoplasms / complications
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Colonic Neoplasms / surgery
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DNA, Viral / blood
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Female
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Filgrastim
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Granulocyte Colony-Stimulating Factor / therapeutic use*
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Humans
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Injections, Intravenous
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Liver Neoplasms / complications
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Liver Neoplasms / secondary
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Neutropenia / drug therapy*
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Neutropenia / etiology
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Neutropenia / virology*
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Parvoviridae Infections / drug therapy*
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Parvoviridae Infections / etiology
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Parvovirus B19, Human / genetics
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Parvovirus B19, Human / immunology
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Parvovirus B19, Human / isolation & purification*
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Pefloxacin / administration & dosage
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Pefloxacin / therapeutic use
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Penicillanic Acid / administration & dosage
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Penicillanic Acid / analogs & derivatives
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Penicillanic Acid / therapeutic use
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Piperacillin / administration & dosage
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Piperacillin / therapeutic use
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Recombinant Proteins
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Tazobactam
Substances
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DNA, Viral
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Recombinant Proteins
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Granulocyte Colony-Stimulating Factor
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Pefloxacin
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Amikacin
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Penicillanic Acid
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Filgrastim
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Tazobactam
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Piperacillin