Abstract
Infant acute leukemia, known to have a poor outcome with conventional therapy, usually has a molecular rearrangement at chromosome band 11q23. The 11q23 translocation partner is typically at 4q21 in infant ALL, but other 11q23 translocation partners occur in infant ALL and AML. The MLL gene at 11q23, and the AF4 gene at 4q21, have been extensively studied to identify heterogeneity of structural rearrangement and prognostic indicators, to look for clues as to etiology, and to improve therapy.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Chromosomes, Human, Pair 11*
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Chromosomes, Human, Pair 4*
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DNA-Binding Proteins / genetics*
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Gene Rearrangement
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Histone-Lysine N-Methyltransferase
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Humans
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Infant
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Leukemia, Myeloid / genetics
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Myeloid-Lymphoid Leukemia Protein
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Nuclear Proteins / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Proto-Oncogenes*
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Transcription Factors*
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Transcription, Genetic
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Transcriptional Elongation Factors
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Translocation, Genetic
Substances
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DNA-Binding Proteins
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KMT2A protein, human
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Nuclear Proteins
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Transcription Factors
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Transcriptional Elongation Factors
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Myeloid-Lymphoid Leukemia Protein
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AFF1 protein, human
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Histone-Lysine N-Methyltransferase