A treatment for tardive dyskinesia and some other extrapyramidal symptoms

J Clin Psychopharmacol. 1997 Jun;17(3):190-3. doi: 10.1097/00004714-199706000-00009.


The effects of the administration of acetazolamide and thiamine (A + T) on the symptoms of tardive dyskinesia (TD) and parkinsonism of 8 elderly and 25 younger chronic hospitalized mental patients were examined in a placebo-controlled, double-blind, counterbalanced two-period cross-over study with initial baselines and intervening washout periods. All patients were maintained on their prestudy psychoactive and anti-Parkinson medications, without alteration, throughout the study. The elderly group received 1.5 g acetazolamide and thiamine per day in three divided doses for 3 weeks. The younger group received 1.5 g thiamine and 2.0 g acetazolamide per day in divided doses for 2 months. Both groups showed a significant decrease in scores on the Abnormal Involuntary Movement Scale (TD) and the Simpson-Angus Neurological Rating Scale (parkinsonism) while on A + T. The A + T effects were unrelated to age, gender, diagnosis, or maintenance medications.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetazolamide / administration & dosage
  • Acetazolamide / therapeutic use*
  • Adult
  • Aged
  • Aged, 80 and over
  • Anticonvulsants / therapeutic use*
  • Antipsychotic Agents / adverse effects
  • Carbonic Anhydrase Inhibitors / therapeutic use*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Dyskinesia, Drug-Induced / drug therapy*
  • Dyskinesia, Drug-Induced / etiology
  • Female
  • Humans
  • Male
  • Mental Disorders / complications
  • Mental Disorders / drug therapy
  • Middle Aged
  • Thiamine / administration & dosage
  • Thiamine / therapeutic use*


  • Anticonvulsants
  • Antipsychotic Agents
  • Carbonic Anhydrase Inhibitors
  • Acetazolamide
  • Thiamine