Hyperinsulinemia and clustering of cardiovascular risk factors in middle-aged hypertensive Finnish men and women

J Hypertens. 1997 May;15(5):475-81. doi: 10.1097/00004872-199715050-00002.


Objective: To examine the relationship between hyperinsulinemia and clusters of cardiovascular risk factors in middle-aged hypertensive patients.

Design: A population-based study.

Setting: Pieksämäki District Health Center, and the Community health Center of the city of Tampere, in central Finland.

Subjects: Hypertensive men and women aged 36, 41, 46, and 51 years (n = 18) in the town of Pieksämäki, and a normotensive control population of 177 subjects aged 40 and 45 years in the city of Tampere.

Main outcome measures: Clusters of obesity (body mass index > 30.0 kg/m2), abdominal adiposity (waist:hip ratio > 1.00 for men and > 0.88 for women), hypertriglyceridemia (> 1.70 mmol/l), a low level of high-density lipoprotein cholesterol (< 1.0 mmol/l in men and < 1.20 mmol/l in women) and abnormal glucose metabolism (impaired glucose tolerance or noninsulin-dependent diabetes as defined by World Health Organization criteria) according to statistical quartiles of the fasting plasma insulin concentration.

Results: Among the hypertensives, there was a 2.0- to 3.6-fold higher risk of having a clustering of the insulin-resistance associated cardiovascular risk factors compared with that of the normotensives. Among the hypertensive subjects in the highest quartile of fasting plasma insulin there was a six- to 12-fold increase in risk associated with having two or more insulin resistance-associated cardiovascular risk factors compared with the subjects in the lowest quartile. There was a positive correlation between a high number of ascertained risk factors and high levels of fasting plasma insulin.

Conclusion: In clinical practice, knowledge of the close relationship between risk-factor cluster status and fasting plasma insulin levels offers a tool to evaluate the occurrence of hyperinsulinemia in middle-aged hypertensive men and women.

MeSH terms

  • Adult
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / etiology*
  • Case-Control Studies
  • Cholesterol, HDL / blood
  • Cluster Analysis
  • Female
  • Finland / epidemiology
  • Glucose / metabolism
  • Humans
  • Hypertension / blood*
  • Hypertension / complications*
  • Hypertension / metabolism
  • Hypertriglyceridemia / complications
  • Hypertriglyceridemia / epidemiology
  • Insulin / blood*
  • Insulin Resistance
  • Male
  • Middle Aged
  • Obesity / complications
  • Obesity / epidemiology
  • Risk Factors


  • Cholesterol, HDL
  • Insulin
  • Glucose