Contrast-to-noise ratio in functional MRI of relative cerebral blood volume with sprodiamide injection

J Magn Reson Imaging. May-Jun 1997;7(3):523-7. doi: 10.1002/jmri.1880070312.


The purpose of this study was to investigate the dependence of contrast-to-noise ratio (CNR) on the dose and rate of sprodiamide injection in magnetic resonance relative cerebral blood volume (rCBV) imaging. rCBV maps for 35 normal volunteers were constructed from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of sprodiamide. Doses of .1, .2, and .3 mmol/kg, at rates of 2 ml/second and 5 ml/second, were tested. CNRs and blood/volume ratios of gray to white matter were computed. CNR depended on dose (P < .0001) but was independent of injection rate (P < .69). rCBV ratios of gray to white matter were dose independent (P < .38) and rate independent (P < .97). The dependence of CNR on dose, but not injection rate, has practical implications in optimal protocol design. The independence of gray/white ratios supports the theory underlying the generation of rCBV maps.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Blood Volume* / physiology*
  • Brain / anatomy & histology*
  • Brain / blood supply*
  • Brain Mapping
  • Contrast Media / administration & dosage*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Organometallic Compounds / administration & dosage*
  • Pentetic Acid / administration & dosage
  • Pentetic Acid / analogs & derivatives*
  • Reference Values
  • Sensitivity and Specificity


  • Contrast Media
  • Organometallic Compounds
  • sprodiamide
  • Pentetic Acid