Abstract
We report the first case in the literature of fatal betaxolol (Kerlone) self-poisoning. After a single-step liquid-liquid alkaline extraction, betaxolol was identified by a high-performance liquid chromatographic-diode array detection screening procedure and then quantitated in cardiac blood, heart, brain, muscle, spleen, stomach contents, duodenum contents, liver, and kidney. The blood betaxolol concentration was 36 mg/L.
MeSH terms
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Adrenergic beta-Antagonists / blood
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Adrenergic beta-Antagonists / metabolism
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Adrenergic beta-Antagonists / poisoning*
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Adult
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Autopsy
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Betaxolol / blood
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Betaxolol / metabolism
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Betaxolol / poisoning*
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Brain / metabolism
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Chromatography, High Pressure Liquid
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Female
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Gastrointestinal Contents / chemistry
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Humans
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Kidney / metabolism
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Liver / metabolism
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Muscles / metabolism
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Myocardium / metabolism
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Reference Standards
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Spleen / metabolism
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Suicide*
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Tissue Distribution
Substances
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Adrenergic beta-Antagonists
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Betaxolol