A fatal case of betaxolol poisoning

J Anal Toxicol. 1997 May-Jun;21(3):228-31. doi: 10.1093/jat/21.3.228.

Abstract

We report the first case in the literature of fatal betaxolol (Kerlone) self-poisoning. After a single-step liquid-liquid alkaline extraction, betaxolol was identified by a high-performance liquid chromatographic-diode array detection screening procedure and then quantitated in cardiac blood, heart, brain, muscle, spleen, stomach contents, duodenum contents, liver, and kidney. The blood betaxolol concentration was 36 mg/L.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic beta-Antagonists / blood
  • Adrenergic beta-Antagonists / metabolism
  • Adrenergic beta-Antagonists / poisoning*
  • Adult
  • Autopsy
  • Betaxolol / blood
  • Betaxolol / metabolism
  • Betaxolol / poisoning*
  • Brain / metabolism
  • Chromatography, High Pressure Liquid
  • Female
  • Gastrointestinal Contents / chemistry
  • Humans
  • Kidney / metabolism
  • Liver / metabolism
  • Muscles / metabolism
  • Myocardium / metabolism
  • Reference Standards
  • Spleen / metabolism
  • Suicide*
  • Tissue Distribution

Substances

  • Adrenergic beta-Antagonists
  • Betaxolol