Spectrum of neuropsychiatric complications in 791 cases of typhoid fever

Trop Med Int Health. 1997 Apr;2(4):314-8. doi: 10.1111/j.1365-3156.1997.tb00145.x.

Abstract

Over a 6-year period, we studied 791 patients with multidrug-resistant typhoid fever, of whom 665 individuals (84%) developed neuropsychiatric manifestations. These were: acute confusional state (73%); myelitis (6%); cerebellitis (1%); parkinsonism (1%); acute psychosis (0.6%); meningo-encephalitis (0.5%); encephalitis (0.25%); sensory motor polyneuropathy, polymyositis, acute schizophrenia and bizarre neurological syndromes (0.12% each). Severe parkinsonian rigidity and meningo-encephalitis are associated with significant morbidity but very low mortality (0.5%).

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Cerebellar Diseases / complications
  • Cerebellar Diseases / diagnosis*
  • Cerebellar Diseases / epidemiology
  • Confusion / complications
  • Confusion / diagnosis*
  • Confusion / epidemiology
  • Drug Resistance, Microbial
  • Drug Resistance, Multiple
  • Encephalitis / complications
  • Encephalitis / diagnosis*
  • Encephalitis / epidemiology
  • Female
  • Humans
  • India / epidemiology
  • Male
  • Meningoencephalitis / complications
  • Meningoencephalitis / diagnosis*
  • Meningoencephalitis / epidemiology
  • Middle Aged
  • Myelitis / complications
  • Myelitis / diagnosis*
  • Myelitis / epidemiology
  • Parkinson Disease / complications
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / epidemiology
  • Polymyositis / complications
  • Polymyositis / diagnosis*
  • Polymyositis / epidemiology
  • Psychotic Disorders / complications
  • Psychotic Disorders / diagnosis*
  • Psychotic Disorders / epidemiology
  • Schizophrenia / complications
  • Schizophrenia / diagnosis*
  • Schizophrenia / epidemiology
  • Typhoid Fever / complications*
  • Typhoid Fever / drug therapy
  • Typhoid Fever / epidemiology

Substances

  • Anti-Bacterial Agents