Kinetics of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after red wine oral administration in rats

Int J Clin Pharmacol Res. 1996;16(4-5):77-81.


Kinetics of trans- and cis-resveratrol (3,4',5-trihydroxystilbene), a natural compound from grape products, have been evaluated in rats after oral administration of red wine. Resveratrol concentrations were measured in plasma, heart, liver and kidneys. Tissue concentrations showed a significant cardiac bioavailability and strong affinity for liver and kidneys.

MeSH terms

  • Administration, Oral
  • Animals
  • Biological Availability
  • Kidney / metabolism
  • Liver / metabolism
  • Male
  • Myocardium / metabolism
  • ROC Curve
  • Rats
  • Rats, Wistar
  • Resveratrol
  • Stilbenes / blood
  • Stilbenes / pharmacokinetics*
  • Tissue Distribution
  • Wine*


  • Stilbenes
  • Resveratrol