[Digoxin in chronic heart failure and sinus rhythm: is the end of the controversy in sight?]

Ned Tijdschr Geneeskd. 1997 Mar 8;141(10):460-4.
[Article in Dutch]


It has for years been a matter of debate whether digoxin may/should be used in chronic heart failure with sinus rhythm. Interest in digoxin was renewed when it was found that the substance had a vagotonic as well as a sympatholytic effect in heart failure patients. A recent clinical trial led to the conclusion that although digoxin had no effect on the mortality among heart failure patients, it did lead to a reduction of the number of hospital admissions, particularly because of heart failure (indicating reduced morbidity and deceleration of the progression of the disease). Many heart failure patients continue to have symptoms in spite of treatment with diuretics and ACE inhibitors. As only few alternatives are available, many physicians in the near future will go on using digoxin in these patients- and as the recent study shows, rightly so.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Anti-Arrhythmia Agents / therapeutic use*
  • Arrhythmias, Cardiac / drug therapy
  • Arrhythmias, Cardiac / physiopathology*
  • Clinical Trials as Topic
  • Digoxin / therapeutic use*
  • Female
  • Heart Failure / drug therapy*
  • Heart Failure / mortality
  • Heart Failure / physiopathology
  • Humans
  • Male
  • Middle Aged


  • Angiotensin-Converting Enzyme Inhibitors
  • Anti-Arrhythmia Agents
  • Digoxin