Wheezing bronchitis reinvestigated at the age of 10 years

Acta Paediatr. 1997 Apr;86(4):351-5. doi: 10.1111/j.1651-2227.1997.tb09021.x.


We have reinvestigated 92/101 children aged 10, who before the age of 2 years were admitted to a paediatric ward due to wheezing bronchitis. At the present time, 70% are symptom-free without medication, 20% have mild asthma, 8% moderate and 2% severe asthma. Persistent asthma correlated significantly to the presence of some other atopic disease in recent years, to early start of wheezing during infancy and to intense obstructive disease as a young child, while initial respiratory syncytial virus infection did not. A clear-cut relationship between smoking in the home in infancy and persistent asthma emerged (not visible at a preschool follow-up). The histamine challenge results correlated to the clinical picture. A normal histamine challenge was seen in 63%, mild hyperresponsiveness in 19%, moderate in 12% and pronounced hyperresponsiveness in 6%. The figures for persistent asthma and bronchial hyperresponsiveness are high compared with the prevalence of asthma in the overall population of schoolchildren.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthma / epidemiology*
  • Asthma / etiology
  • Bronchitis / complications
  • Bronchitis / epidemiology*
  • Bronchitis / virology
  • Follow-Up Studies
  • Histamine
  • Humans
  • Hypersensitivity, Immediate / epidemiology
  • Hypersensitivity, Immediate / etiology
  • Infant
  • Respiratory Sounds* / etiology
  • Respiratory Syncytial Virus Infections / complications
  • Respiratory Syncytial Virus Infections / epidemiology
  • Retrospective Studies
  • Severity of Illness Index
  • Sweden / epidemiology
  • Tobacco Smoke Pollution / adverse effects


  • Tobacco Smoke Pollution
  • Histamine