Neurobehavioral evaluation of lurcher mutant mice during ontogeny

Brain Res Dev Brain Res. 1997 May 20;100(1):22-8. doi: 10.1016/s0165-3806(97)00010-2.


Lurcher mutant mice were compared to normal littermate controls for body weight, body righting, negative geotropism, sensorimotor coordination (rotating grid, wire suspension, rotorod), and visuomotor coordination requiring swimming toward a pole during postnatal (P) days 0-30. Lurcher mutants had a lower body weight on P20-P30 and were slower before performing the complete body righting response on P13-P30. Because of postural instability during the negative geotropism test, lurcher mutants turned quicker up the slope than normal mice. The mutants fell sooner from the rotating grid on P11-P14, from the horizontal wire on P15-P16, and from the rotorod on P14-P30. Lurcher mutants were also slower before swimming to the pole or climbing to the top of the pole and were inferior in pole climbing height on P22-P30. These results indicate test-selective and time-selective neurobehavioral deficits during ontogeny in a spontaneous cerebellar mutant.

Publication types

  • Comparative Study

MeSH terms

  • Aging / physiology*
  • Animals
  • Animals, Newborn
  • Body Weight
  • Crosses, Genetic
  • Female
  • Male
  • Mice
  • Mice, Neurologic Mutants / physiology*
  • Motor Activity
  • Posture
  • Psychomotor Performance
  • Reference Values
  • Rotation
  • Swimming