Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens

J Ethnopharmacol. 1997 Apr;56(2):165-9. doi: 10.1016/s0378-8741(97)01514-6.

Abstract

The in vitro antiviral activity of galangin (3,5,7-trihydroxyflavone), the major antimicrobial compound isolated from the shoots of Helichrysum aureonitens, was investigated against herpes simplex virus type 1 (HSV-1), coxsackie B virus type 1 (Cox B1), adenovirus type 31 (Ad31) and reovirus. At concentrations ranging from 12-47 micrograms/ml galangin showed significant antiviral activity against HSV-1 and CoxB1, limited activity against reovirus, and no antiviral activity against Ad31.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviruses, Human / drug effects*
  • Animals
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Carcinoma, Hepatocellular / pathology
  • Cells, Cultured
  • Enterovirus B, Human / drug effects*
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Haplorhini
  • Herpesvirus 1, Human / drug effects*
  • Humans
  • Kidney / cytology
  • Liver Neoplasms / pathology
  • Mutagens / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Shoots / chemistry
  • Plant Shoots / metabolism
  • Plants, Medicinal / chemistry
  • Reoviridae / drug effects*
  • South Africa
  • Tumor Cells, Cultured

Substances

  • Antiviral Agents
  • Flavonoids
  • Mutagens
  • Plant Extracts
  • galangin