Interferon-gamma receptors in nociceptive pathways: role in neuropathic pain-related behaviour

Neuroreport. 1997 Mar 24;8(5):1311-6. doi: 10.1097/00001756-199703240-00050.


Interferon-gamma receptor (IFN-gamma R) immunoreactivity was observed in the superficial dorsal horn and lateral spinal nucleus in rat and mouse spinal cord. Dorsal rhizotomies did not reduce immunoreactivity in the rat. IFN-gamma R distribution overlapped with nitric oxide synthase-1 immunoreactivity. In wild-type mice, intrathecal injections of mouse IFN-gamma evoked biting behaviour, whereas mice with disruption of the functional gene for IFN-gamma R did not respond. Both types of mice had similar withdrawal thresholds to mechanical stimulation and reacted similarly to foot-pad carrageenan injections. In contrast to wild-type mice, IFN-gamma R knock-out mice did not show autotomy after sciatic nerve section. This study demonstrates a functional IFN-gamma R in spinal nociceptive pathways related to neuropathic pain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Female
  • Immunohistochemistry
  • Interferon-gamma / pharmacology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neural Pathways / physiology
  • Neuralgia / physiopathology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Interferon / physiology*
  • Recombinant Proteins
  • Spinal Cord / physiopathology*
  • Synaptic Transmission / physiology*


  • Receptors, Interferon
  • Recombinant Proteins
  • Interferon-gamma