High Prevalence of the CagA-positive Helicobacter Pylori Strains in Japanese Asymptomatic Patients and Gastric Cancer Patients

Scand J Gastroenterol. 1997 May;32(5):465-8. doi: 10.3109/00365529709025082.

Abstract

Background: Several studies have shown that infection of Helicobacter pylori strains possessing cagA is associated with atrophic gastritis and gastric cancers.

Method: In 58 pairs of early gastric cancer patients and sex- and age-matched controls, isolated H. pylori strains were tested for possession of cagA. The presence of atrophic gastritis was also examined.

Results: Proportions of cagA-positive strains were 100% in cancer patients and 92.3% in controls. Atrophic gastritis was seen in 96.7% and 95.8% of cancer and control patients in whom cagA-positive strains (NS) were detected. However, it was seen in only 20% of H. pylori-negative control patients (P < 0.01).

Conclusions: The present results do not suggest any specific association between cagA-positive strains and gastric cancer. However, frequent prevalence of cagA-positive strains might be associated with the high incidence of atrophic gastritis in Japanese populations.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Bacterial*
  • Bacterial Proteins / genetics*
  • Biopsy
  • DNA Primers / chemistry
  • DNA, Bacterial / analysis
  • Female
  • Gastric Mucosa / microbiology*
  • Gastric Mucosa / pathology
  • Gastritis, Atrophic / epidemiology
  • Gastritis, Atrophic / microbiology
  • Gastritis, Atrophic / pathology
  • Gastroscopy
  • Helicobacter Infections / epidemiology
  • Helicobacter Infections / microbiology*
  • Helicobacter Infections / pathology
  • Helicobacter pylori / genetics*
  • Helicobacter pylori / isolation & purification
  • Humans
  • Incidence
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Prevalence
  • Prospective Studies
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / microbiology*
  • Stomach Neoplasms / pathology

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • DNA Primers
  • DNA, Bacterial
  • cagA protein, Helicobacter pylori