Two-component signal transducers and MAPK cascades

Trends Biochem Sci. 1997 May;22(5):172-6. doi: 10.1016/s0968-0004(97)01036-0.


Two-component signal transducers, which are characterized by the histidine-to-aspartate phospho-transfer mechanism, were once thought to be restricted to prokaryotes. They have, however, now been identified in diverse eukaryotic species including plant, fungus, yeast and slime mold. In yeast, a two-component osmosensor has been found to regulate a mitogen-activated protein kinase (MAPK) cascade, a ubiquitous eukaryotic signaling module.

Publication types

  • Review

MeSH terms

  • Bacterial Outer Membrane Proteins
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Escherichia coli Proteins*
  • Eukaryotic Cells
  • Multienzyme Complexes*
  • Phosphorylation
  • Plants
  • Prokaryotic Cells
  • Saccharomyces cerevisiae
  • Signal Transduction*


  • Bacterial Outer Membrane Proteins
  • Escherichia coli Proteins
  • Multienzyme Complexes
  • Calcium-Calmodulin-Dependent Protein Kinases
  • envZ protein, E coli