Abstract
The antibacterial activity of tazobactam-piperacillin was compared with that of sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam-cefoperazone and piperacillin against beta-lactamase-producing bacteria isolated from patients with complicated urinary tract infections. Tazobactam-piperacillin showed a broad antibacterial spectrum against gram-negative and gram-positive bacteria. The minimum inhibitory concentrations (MIC90) of tazobactam-piperacillin were 6.25 micrograms/ml against Escherichia coli, 1.56 micrograms/ml against Proteus mirabilis, 3.13 micrograms/ml against Proteus vulgaris, 6.25 micrograms/ml against methicillin-susceptible Staphylococcus aureus, and 6.25 micrograms/ml coagulase-negative methicillin-susceptible staphylococci. Against all beta-lactamase-producing bacteria tested the antibacterial activity of tazobactam-piperacillin was at least 4- to 64-fold stronger than that of piperacillin, clavulanic acid-ticarcillin, and sulbactam-ampicillin, and similar to or greater than that of sulbactam-cefoperazone except for E. coli.
MeSH terms
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Ampicillin / pharmacology
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Cefoperazone / pharmacology
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Cephalosporins / pharmacology
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Clavulanic Acid
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Clavulanic Acids / pharmacology
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Colony Count, Microbial
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Dose-Response Relationship, Drug
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Drug Therapy, Combination / pharmacology*
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Enzyme Inhibitors / pharmacology
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Gram-Negative Bacteria / drug effects*
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Gram-Negative Bacteria / growth & development
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Gram-Negative Bacteria / isolation & purification
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Gram-Negative Bacterial Infections / drug therapy
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Gram-Negative Bacterial Infections / microbiology*
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Humans
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Microbial Sensitivity Tests
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Penicillanic Acid / analogs & derivatives
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Penicillanic Acid / pharmacology
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Penicillins / pharmacology
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Piperacillin / pharmacology
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Retrospective Studies
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Sulbactam / pharmacology
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Tazobactam
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Ticarcillin / pharmacology
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Urinary Tract / microbiology*
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Urinary Tract Infections / drug therapy
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Urinary Tract Infections / microbiology*
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beta-Lactamase Inhibitors
Substances
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Cephalosporins
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Clavulanic Acids
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Enzyme Inhibitors
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Penicillins
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beta-Lactamase Inhibitors
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Clavulanic Acid
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Ampicillin
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Cefoperazone
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Penicillanic Acid
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Ticarcillin
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Sulbactam
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Tazobactam
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Piperacillin