E-cadherin engagement stimulates tyrosine phosphorylation

Cell Adhes Commun. 1997 Mar;4(6):425-37. doi: 10.3109/15419069709004459.


Cadherins are cell adhesion molecules concentrated at intercellular adherens junctions, where they form a multiprotein complex with cytoplasmic catenins. Although cell-cell interactions affect many aspects of cell behavior, little is known about signaling pathways triggered by cadherin engagement. We show here that E-cadherin-mediated cell-cell adhesion leads to a rapid increase in tyrosine phosphorylation at sites of cell-cell contact and that this stimulation of tyrosine phosphorylation can be mimicked by aggregation of E-cadherin with antibodies. The proteins that become phosphorylated are distinct from those previously shown to be tyrosine phosphorylated in response to integrin-mediated adhesion and include ras-GAP. We also find that E-cadherin-mediated tyrosine phosphorylation is not required for the assembly of adherens-type junctions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cadherins / metabolism*
  • Cell Adhesion*
  • Cell Line
  • Humans
  • Intercellular Junctions
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism
  • Tyrosine / metabolism*


  • Cadherins
  • Tyrosine
  • Protein-Tyrosine Kinases