Camguk, Lin-2, and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains

Mech Dev. 1997 Apr;63(1):127-30. doi: 10.1016/s0925-4773(97)00668-0.


MAGUKs (membrane-associated guanylate kinase homologs) are proteins involved in cell junction organization, tumor suppression, and signalling. Their structure includes one or three copies of a DHR or PDZ domain (discs-large homologous region or PSD-95/SAP90, discs-large ZO-1 homologous domain), an SH3 domain, and a guanylate kinase domain. MAGUKs were classified into two subfamilies: Dlg-like with three DHR/PDZ domains and p55-like with a single DHR/PDZ domain. There is now a new subfamily whose members have a novel domain structure: a calcium/calmodulin-dependent protein kinase domain in the N-terminus as well as the DHR/PDZ, SH3 and GUK domains in the C-terminus. These new MAGUKs may regulate transmembrane molecules that bind calcium, calmodulin, or nucleotides, camguk (cmg) is a Drosophila member of this novel MAGUK subfamily; we report its sequence and domain structure.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis elegans / metabolism
  • Calcium-Calmodulin-Dependent Protein Kinases / chemistry*
  • Drosophila / metabolism
  • Drosophila Proteins*
  • Guanylate Kinases
  • Helminth Proteins / biosynthesis
  • Helminth Proteins / chemistry*
  • Humans
  • Membrane Proteins / biosynthesis
  • Membrane Proteins / chemistry*
  • Molecular Sequence Data
  • Nucleoside-Phosphate Kinase / biosynthesis
  • Nucleoside-Phosphate Kinase / chemistry*
  • Rats
  • Sequence Homology, Amino Acid
  • Signal Transduction


  • Drosophila Proteins
  • Helminth Proteins
  • Lin-2 protein, C elegans
  • Membrane Proteins
  • CASK kinases
  • CASK protein, Drosophila
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Nucleoside-Phosphate Kinase
  • Guanylate Kinases

Associated data

  • GENBANK/M64925
  • GENBANK/S65724
  • GENBANK/U47110
  • GENBANK/U53190
  • GENBANK/X92564