Enhanced immunostimulation by novel platinum anticancer agents

Anticancer Drugs. 1997 Apr;8(4):323-8. doi: 10.1097/00001813-199704000-00003.

Abstract

'Poly-plat', SSP and SAP are second generation analogs of cisplatin which have been shown to activate murine peritoneal macrophages in vivo and in vitro. Murine peritoneal macrophages treated with 'poly-plat', SSP or SAP (5 microg/mg) for 2 h are stimulated to form cytoplasmic extensions. Drug-treated macrophages also elicit an increase in the number of lysosomes. In addition, analysis of tissue culture supernatants shows increased levels of interleukin-1alpha and tumor necrosis factor-alpha. These results show that 'poly-plat', SSP and SAP enhance the immune system with greater efficacy and potency than cisplatin.

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cells, Cultured
  • Cisplatin / analogs & derivatives*
  • Interleukin-1 / metabolism
  • Lysosomes / drug effects
  • Macrophage Activation / drug effects
  • Macrophages, Peritoneal / drug effects*
  • Macrophages, Peritoneal / immunology*
  • Macrophages, Peritoneal / metabolism
  • Mice
  • Organoplatinum Compounds / pharmacology*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Interleukin-1
  • Organoplatinum Compounds
  • Tumor Necrosis Factor-alpha
  • Cisplatin