Signet-ring carcinoma of the prostate

Pathol Res Pract. 1996 Dec;192(12):1232-8; discussion 1239-41. doi: 10.1016/S0344-0338(96)80156-7.


A case of prostatic signet-ring adenocarcinoma is described in a man with a history of open prostatectomy for prostate carcinoma (18 years previously). Immunostaining confirmed the prostatic origin of the signet-ring tumor which stained for prostatic acid phosphatase (PSAP) and prostate specific antigen (PSA). Cytokeratin immunostaining showed the vacuoles to be true lamina with clear and distinct outlines, the feature confirmed by ultrastructural examination. This aggressive tumor is an uncommon but distinct variant of primary prostatic carcinoma which should be distinguished from artefactual vacuolation of tumor, inflammatory and stromal cells, and metastatic disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Carcinoma, Signet Ring Cell / chemistry*
  • Carcinoma, Signet Ring Cell / pathology
  • Diagnosis, Differential
  • Fatal Outcome
  • Humans
  • Immunohistochemistry
  • Keratins / analysis*
  • Male
  • Microscopy, Electron
  • Neoplasm Recurrence, Local / chemistry
  • Neoplasm Recurrence, Local / pathology
  • Prostate-Specific Antigen / analysis*
  • Prostatic Neoplasms / chemistry*
  • Prostatic Neoplasms / pathology


  • Keratins
  • Prostate-Specific Antigen