The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions

Curr Opin Lipidol. 1997 Apr;8(2):111-7. doi: 10.1097/00041433-199704000-00009.


Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arachidonate 15-Lipoxygenase / genetics
  • Arachidonate 15-Lipoxygenase / metabolism*
  • Arteriosclerosis / enzymology*
  • Gene Expression Regulation
  • Humans


  • Arachidonate 15-Lipoxygenase