IgA immune complexes in Henoch-Schönlein purpura

Lancet. 1979 Nov 24;2(8152):1100-3. doi: 10.1016/s0140-6736(79)92505-4.

Abstract

Raised levels of IgA immune complexes were found in 13 of 18 children with Henoch-Schönlein purpura irrespective of whether they developed nephritis or not. In contrast, only those children who developed nephritis had raised levels of IgG immune complexes as well. In 2 children with nephritis, two discrete peaks of IgA complexes were found, corresponding to 4 x 10(5) to 8 x 10(5) and 2.5 x 10(6) to 4 x 10(6) daltons. IgG complexes were found only in the larger-molecular-weight peak. Such differences in immune complexes may underlie the different manifestations of this disease.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Antigen-Antibody Complex*
  • Child
  • Child, Preschool
  • Complement C1 / analysis
  • Female
  • Humans
  • Hypergammaglobulinemia / complications
  • Immune Complex Diseases / immunology*
  • Immunoglobulin A / analysis
  • Immunoglobulin A / immunology*
  • Immunoglobulin G / analysis
  • Male
  • Nephritis / etiology
  • Nephritis / immunology
  • Purpura, Schoenlein-Henoch / complications
  • Purpura, Schoenlein-Henoch / immunology*

Substances

  • Antigen-Antibody Complex
  • Complement C1
  • Immunoglobulin A
  • Immunoglobulin G