Systemic lupus erythmatosus associated with autoimmune hepatitis two cases with novel autoantibodies to transfer RNA-related antigens

Clin Rheumatol. 1997 May;16(3):305-9. doi: 10.1007/BF02238968.


Two cases of systemic lupus erythematosus (SLE) with autoimmune hepatitis are reported. Both patients had a mild form of SLE without central nervous system or renal involvement and showed a rapid response to corticosteroid therapy. Neither of them had antibodies to mitochondria, smooth muscle, and liver/kidney microsome-1 related to autoimmune hepatitis. Instead, novel autoantibodies which react with transfer RNA-related antigen were detected. These autoantibodies could be a useful marker for classification of SLE associated with autoimmune hepatitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autoantibodies / analysis*
  • Autoimmune Diseases / complications*
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / immunology
  • Biomarkers / blood
  • Diagnosis, Differential
  • Female
  • Hepatitis, Chronic / complications*
  • Hepatitis, Chronic / diagnosis
  • Hepatitis, Chronic / immunology
  • Humans
  • Liver / immunology
  • Liver / pathology
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / immunology
  • RNA, Transfer / immunology*


  • Autoantibodies
  • Biomarkers
  • RNA, Transfer