Genes for interleukin-2 receptor beta chain, interleukin-1 beta, and schizophrenia: no evidence for the association or linkage

Am J Med Genet. 1997 May 31;74(3):338-41. doi: 10.1002/(sici)1096-8628(19970531)74:3<338::aid-ajmg17>;2-p.


We studied a CA repeat polymorphism of the interleukin-2 receptor beta chain (IL-2RB) gene and a C/-514/T variation of the interleukin-1 beta (IL-1B) gene in Japanese schizophrenia patients. Both a case-control association study (54 patients and 54 controls) and a linkage study using six multiplex families (the number of the affected > or =4 in each family) were employed. No evidence for the association or the linkage was obtained either for the IL-2RB or IL-1B gene.

MeSH terms

  • Alleles
  • Case-Control Studies
  • Dinucleotide Repeats
  • Genetic Linkage*
  • Genotype
  • Humans
  • Interleukin-1 / genetics*
  • Japan
  • Lod Score
  • Polymorphism, Genetic
  • Receptors, Interleukin-2 / genetics*
  • Schizophrenia / genetics*


  • Interleukin-1
  • Receptors, Interleukin-2