Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis

J Antimicrob Chemother. 1997 May;39(5):643-6. doi: 10.1093/jac/39.5.643.


The influence of various concentrations (0.003-8 mg/mL) of N-acetylcysteine on the formation of biofilms by 15 strains of Staphylococcus epidermidis has been studied. A dose-related decrease in biofilm formation was observed, except with the lowest concentrations. The 'slime' index relative to the control was 63%, 55%, 46%, 34%, 26% and 26% in the presence of 0.25, 0.5, 1, 2, 4, and 8 mg/mL of N-acetylcysteine, respectively. These data are statistically significant. The inhibitory effect of 2 mg/mL of N-acetylcysteine on slime formation was also verified by electron microscopy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcysteine / pharmacology*
  • Bacterial Adhesion / drug effects
  • Biofilms / growth & development*
  • Staphylococcus epidermidis / drug effects*
  • Staphylococcus epidermidis / physiology


  • Acetylcysteine