Variation in plasma fibrinogen over one year: relationships with genetic polymorphisms and non-genetic factors

Thromb Haemost. 1997 May;77(5):884-9.


We analyzed plasma fibrinogen level in relation to genetic polymorphisms in the alpha- and beta-fibrinogen gene loci. Furthermore, the association of other CVD risk markers with fibrinogen was studied twice, with a time interval of one year in 50 to 60 year old men (n = 183). DNA polymorphisms were detected by PCR and digestion with Taq I (alpha-fibrinogen), Hind III and Bcl I (beta-fibrinogen) restriction enzymes. The correlation coefficient between fibrinogen measurements was 0.48 (p < 0.001). Blood leucocytes and waist-to-hip circumference ratio were the strongest correlates of fibrinogen level in both examinations, and the changes in leucocyte count and plasma fibrinogen correlated positively (r = 0.40, p < 0.001). In Eastern Finnish men, the Taq I, Hind III or Bcl I restriction fragment length polymorphisms of the alpha- or beta-fibrinogen gene loci did not associate with fibrinogen level, either cross-sectionally or longitudinally.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers
  • Body Constitution
  • Cholesterol, HDL / blood
  • Cohort Studies
  • Coronary Disease / epidemiology
  • Deoxyribonuclease HindIII
  • Deoxyribonucleases, Type II Site-Specific
  • Energy Metabolism
  • Fibrinogen / analysis
  • Fibrinogen / genetics*
  • Fibrinogen / metabolism*
  • Finland
  • Humans
  • Leukocyte Count
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Oxygen Consumption
  • Polymorphism, Restriction Fragment Length*
  • Random Allocation
  • Risk Factors
  • Time Factors


  • Biomarkers
  • Cholesterol, HDL
  • Fibrinogen
  • Deoxyribonuclease HindIII
  • endodeoxyribonuclease BclI
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases