Micronized flavonoid therapy in internal hemorrhoids of pregnancy

Int J Gynaecol Obstet. 1997 May;57(2):145-51. doi: 10.1016/s0020-7292(97)02889-0.

Abstract

Objective: To assess the safety, efficacy and acceptability of a micronized flavonoid formulation in the treatment of internal hemorrhoids of pregnancy.

Methods: In an open study on hospital outpatients, we studied therapy with micronized diosmin 90% and hesperidin 10% for a median of 8 weeks before delivery and 4 weeks after delivery, in 50 women with acute hemorrhoids. The outcome measures were symptoms and signs of hemorrhoids; adverse effects; and acceptability of treatment.

Result: On intention to treat analysis, 66% (95% confidence interval, range 79.1-52.9) had relief from acute symptoms by the 4th day; 53.6% (95% confidence interval, range 70-37.1, P < 0.001) fewer patients had relapse in the antenatal period. Treatment was well accepted, and did not affect pregnancy, fetal development, birth weight, infant growth and feeding.

Conclusion: In the short term, micronized diosmin 90% and hesperidin 10% is safe, acceptable, and effective in the treatment of hemorrhoids of pregnancy.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Acute Disease
  • Administration, Oral
  • Adult
  • Chi-Square Distribution
  • Confidence Intervals
  • Diosmin / administration & dosage*
  • Dose-Response Relationship, Drug
  • Drug Compounding
  • Female
  • Hemorrhoids / drug therapy*
  • Hemorrhoids / etiology
  • Hesperidin / administration & dosage*
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Pregnancy Outcome*
  • Prospective Studies
  • Treatment Outcome

Substances

  • Diosmin
  • Hesperidin