Possible association of infertility with sperm-specific abnormality of CD46

J Reprod Immunol. 1997 Apr;33(1):83-8. doi: 10.1016/s0165-0378(97)01017-6.


Three infertile patients fulfilling normal or subnormal criteria on routine semen analysis showed abnormal sperm CD46 (membrane cofactor protein of complement) by SDS-PAGE/immunoblotting analysis using a panel of monoclonal antibodies. The sperm CD46 isoform has been reported to be associated with sperm-egg interaction. These three patients expressed normal CD46 isoforms on their lymphocytes and granulocytes. Sperm-specific abnormalities in these proteins thus parallel male infertility, suggesting a new category of infertility, probably due to aberrations in the molecules related to sperm-egg interaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrosome / immunology
  • Adult
  • Antigens, CD / analysis*
  • Antigens, CD / genetics
  • Epitope Mapping
  • Female
  • Humans
  • Infertility, Male / immunology*
  • Infertility, Male / pathology
  • Male
  • Membrane Cofactor Protein
  • Membrane Glycoproteins / analysis*
  • Membrane Glycoproteins / genetics
  • Spermatozoa / chemistry
  • Spermatozoa / immunology*
  • Spermatozoa / pathology


  • Antigens, CD
  • CD46 protein, human
  • Membrane Cofactor Protein
  • Membrane Glycoproteins