New evidence for neurotransmitter influences on brain development

Trends Neurosci. 1997 Jun;20(6):269-74. doi: 10.1016/s0166-2236(96)01028-4.


The early appearance of monoamine systems in the developing mammalian CNS suggests that they play a role in neural development. We review data from two model systems that provide compelling new evidence of this role. In one model system-in utero exposure to cocaine-specific and robust alterations are seen in dopamine-rich areas of the cerebral cortex, such as the anterior cingulate cortex: D1 receptor-G protein coupling is greatly reduced, the GABAergic system is altered and pyramidal dendrites undergo excessive growth. In a second model system-a transgenic mouse line in which the gene that encodes monoamine oxidase A (MAOA) is disrupted, resulting in excessively high 5-HT levels-barrels fail to form in the developing somatosensory cortex. Both models reveal the effects of very early manipulation of monoamines on forebrain development, and the long-term anomalies that persist into adulthood.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / embryology
  • Brain / growth & development*
  • Cocaine / toxicity
  • Female
  • Mice
  • Mice, Transgenic
  • Neurotransmitter Agents / physiology*
  • Pregnancy
  • Prenatal Exposure Delayed Effects


  • Neurotransmitter Agents
  • Cocaine