Elevated fecal levels of endogenous pancreatic endopeptidases after antibiotic treatment

Scand J Gastroenterol. 1977;12(5):525-9. doi: 10.3109/00365527709181329.


Feces from normal and antibiotic-treated persons were analyzed for the content of immunoreactive trypsin and elastase. In the control group the mean concentration of immunoreactive trypsin was 13 microgram per g feces as compared to 147 in the antibiotic-treated group. Elastase was demonstrable in only 3 of 30 samples in the control group but in 20 of 26 in the antibiotic-treated group. The decreased inactivation of pancreatic proteases must depend on an altered intestinal microflora. The results suggest that reestablishment of a normal enteric flora may take months after the short time oral administration of antibiotics.

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Doxycycline / adverse effects
  • Feces / enzymology*
  • Humans
  • Pancreatic Elastase / analysis*
  • Pancreatic Juice / enzymology*
  • Penicillins / adverse effects
  • Tetracycline / adverse effects
  • Trypsin / analysis*


  • Anti-Bacterial Agents
  • Penicillins
  • Pancreatic Elastase
  • Trypsin
  • Tetracycline
  • Doxycycline