Cytomegalovirus-associated acute retinal necrosis syndrome

Am J Ophthalmol. 1997 Feb;123(2):257-8. doi: 10.1016/s0002-9394(14)71046-3.


Purpose: To describe a case of acute retinal necrosis syndrome in which a polymerase chain reaction-based assay provided evidence for cytomegalovirus as the causative agent of the syndrome.

Methods: Polymerase chain reaction-based assays were used to analyze a vitreous aspirate from a 70-year-old man with acute retinal necrosis syndrome. The specimen was tested for cytomegalovirus, varicella-zoster virus, and herpes simplex virus type 1 and type 2.

Results: The polymerase chain reaction assay for cytomegalovirus was positive, and polymerase chain reaction assays for varicella-zoster virus and herpes simplex virus type 1 and type 2 were negative.

Conclusion: Cytomegalovirus may be a causative agent of acute retinal necrosis syndrome.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Cytomegalovirus / genetics
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / complications*
  • DNA, Viral / analysis
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Retinal Necrosis Syndrome, Acute / virology*


  • DNA, Viral