Evidence of optic pathway gliomas after previously negative neuroimaging

Ophthalmology. 1997 Jun;104(6):930-5. doi: 10.1016/s0161-6420(97)30205-x.


Purpose: The authors emphasize the potential for the development of anterior visual pathway gliomas, evidenced by computed tomography (CT) or magnetic resonance imaging (MRI) scans, in neurofibromatosis type 1 (NF1) patients who previously had normal neuroimaging studies.

Methods: The clinic charts and CT and MRI scans were retrospectively reviewed for all patients evaluated at the neurofibromatosis clinic of one referral center over a period of 7 years. Patients with neuroimaging studies demonstrating anterior visual pathway gliomas who previously had normal scans were identified, and their cases are described in detail. A similar, previously reported series, from the pediatric literature, was also reviewed.

Results: Eight percent (28/360) of patients had CT or MRI scans revealing optic gliomas. Two of these patients had normal neuroimaging studies previously.

Conclusion: A negative neuroimaging study in an NF1 patient does not exclude the future development of an optic glioma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child, Preschool
  • Cranial Nerve Neoplasms / diagnosis*
  • Cranial Nerve Neoplasms / drug therapy
  • False Negative Reactions
  • Female
  • Glioma / diagnosis*
  • Glioma / drug therapy
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male
  • Optic Chiasm / diagnostic imaging
  • Optic Chiasm / pathology
  • Optic Nerve Diseases / diagnosis*
  • Optic Nerve Diseases / drug therapy
  • Retrospective Studies
  • Tomography, X-Ray Computed / methods*
  • Visual Pathways / diagnostic imaging
  • Visual Pathways / pathology*