Clinical relevance of Fc gamma receptor polymorphisms

Ann N Y Acad Sci. 1997 Apr 5;815:282-95. doi: 10.1111/j.1749-6632.1997.tb52070.x.

Abstract

Human IgG receptors are very heterogeneous and we currently distinguish three Fc gamma receptor classes specifying at least 12 receptor isoforms. On top of this complexity, Fc gamma R are further found to differ between different individuals. Polymorphisms have been identified for all three Fc gamma R classes. The best-studied ones represent allelic variation of Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16). The Fc gamma RIIa polymorphism is now considered to be a heritable risk factor for autoimmune and infectious diseases, and support for a relevant role of the IIIb polymorphism has also been obtained. A detailed analysis of the exact contribution of each of these Fc gamma R polymorphisms in relation to previously implicated risk factors should unravel the pathophysiological importance of Fc gamma R polymorphisms in the near future.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use
  • Autoimmune Diseases / genetics*
  • Granulomatosis with Polyangiitis / genetics
  • Heparin
  • Humans
  • Kidney Transplantation
  • Lupus Erythematosus, Systemic / genetics
  • Mice
  • Models, Molecular
  • Polymorphism, Genetic*
  • Receptors, IgG / genetics*
  • Receptors, IgG / immunology
  • Thrombocytopenia / genetics

Substances

  • Antibodies, Monoclonal
  • Receptors, IgG
  • Heparin