A paradoxical effect of bronchodilators

Chest. 1997 Jun;111(6):1766-7. doi: 10.1378/chest.111.6.1766.


Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acidosis, Lactic / chemically induced*
  • Acute Disease
  • Adrenergic beta-Agonists / adverse effects*
  • Albuterol / adverse effects*
  • Asthma / complications
  • Asthma / drug therapy
  • Bronchodilator Agents / adverse effects*
  • Dyspnea / chemically induced
  • Humans
  • Male
  • Middle Aged


  • Adrenergic beta-Agonists
  • Bronchodilator Agents
  • Albuterol