Contagious caprine pleuropneumonia (CCPP) is now a well-defined disease that is caused by Mycoplasma capricolum subsp. capripneumoniae. CCPP is infectious, contagious and fulfils the classic Koch postulates that characterise such types of disease. The distribution of the disease is not exactly known, but reports of mycoplasma isolation and official declarations to the Office International des Epizooties (OIE) enable a probable distribution map to be obtained. There are many other mycoplasmas that can infect goat and sheep lungs and induce pleuropneumonia. However, pleuropneumonia is often restricted to young animals and the prominent symptom is mastitis in lactating does. Other symptoms may also occur, contributing to a syndrome that has been tentatively described in this paper as 'MAKePS syndrome' for mastitis, arthritis, keratitis, pneumonia and septicaemia.