Polysaccharopeptide from Coriolus versicolor has potential for use against human immunodeficiency virus type 1 infection

Life Sci. 1997;60(25):PL383-7. doi: 10.1016/s0024-3205(97)00294-4.


Polysaccharopeptide (PSP) isolated from the edible mushroom Coriolus versicolor was tested for its potential as an anti-human immunodeficiency virus type 1 (HIV-1) compound in a series of in vitro assays. It demonstrated inhibition of the interaction between HIV-1 gp 120 and immobilized CD4 receptor (IC50 = 150 microg/ml), potent inhibition of recombinant HIV-1 reverse transcriptase (IC50 = 6.25 microg/ml), and inhibited a glycohydrolase enzyme associated with viral glycosylation. These properties, coupled with its high solubility in water, heat-stability and low cytotoxicity, make it a useful compound for further studies on its possible use as an anti-viral agent in vivo.

MeSH terms

  • Adjuvants, Immunologic / pharmacology
  • Anti-HIV Agents / pharmacology*
  • Antineoplastic Agents / pharmacology
  • Basidiomycota
  • CD4 Antigens / metabolism
  • Glycoside Hydrolases / antagonists & inhibitors
  • HIV Envelope Protein gp120 / metabolism
  • HIV Infections / drug therapy*
  • HIV Reverse Transcriptase / drug effects
  • HIV-1 / drug effects*
  • HIV-1 / metabolism
  • Humans
  • Immunoenzyme Techniques
  • Proteoglycans / pharmacology*
  • Reverse Transcriptase Inhibitors / pharmacology


  • Adjuvants, Immunologic
  • Anti-HIV Agents
  • Antineoplastic Agents
  • CD4 Antigens
  • HIV Envelope Protein gp120
  • Proteoglycans
  • Reverse Transcriptase Inhibitors
  • polysaccharide peptide
  • HIV Reverse Transcriptase
  • Glycoside Hydrolases