General principles of wound healing

Surg Clin North Am. 1997 Jun;77(3):509-28. doi: 10.1016/s0039-6109(05)70566-1.


Wound healing is a complex process involving different biologic and immunologic systems. Despite improvements in diagnostics and therapy, wound failures remain a clinical problem. The approach to a nonhealed wound is an interdisciplinary challenge that should not be underestimated. Better understanding of the complex wound-healing cascade helps our approach to wound healing and its possible failure. Manipulations of the involved immunologic features offer future therapeutic strategies.

Publication types

  • Review

MeSH terms

  • Cell Division
  • Chemotaxis
  • Cicatrix / physiopathology
  • Collagen / metabolism
  • Cytokines / analysis
  • Extracellular Matrix / metabolism
  • Hemostasis / physiology
  • Humans
  • Macrophage Activation
  • Wound Healing / immunology
  • Wound Healing / physiology*


  • Cytokines
  • Collagen