Allelic loss on chromosome 11 is uncommon in parathyroid glands of patients with hypercalcaemic secondary hyperparathyroidism

Eur J Surg. 1997 May;163(5):331-7.


Objective: To test the hypothesis that progression of secondary hyperparathyroidism from normocalcaemia to hypercalcaemia occurs because of development of monoclonal parathyroid tumours after the inactivation of a tumour suppressor gene on chromosome 11q13.

Design: Experimental study.

Setting: University hospital, Sweden.

Subjects: 13 Patients with secondary hypercalcaemic hyperparathyroidism.

Interventions: 48 Parathyroid glands were removed, 39 of which were analysed using Southern blot hybridisation and polymerase chain reaction.

Main outcome measures: Loss of heterozygosity on several loci on chromosome 11, including 11q13, which carries the presumed gene for multiple endocrine neoplasia type 1 (MEN1).

Results: Monosomy for chromosome 11 was found in one tumour.

Conclusions: It seems unlikely that the MEN1 gene is of importance in the progression of secondary hyperparathyroidism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alleles
  • Child
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 11 / genetics*
  • Disease Progression
  • Female
  • Heterozygote
  • Humans
  • Hypercalcemia / etiology
  • Hypercalcemia / genetics
  • Hyperparathyroidism, Secondary / complications
  • Hyperparathyroidism, Secondary / genetics*
  • Hyperplasia
  • Male
  • Middle Aged
  • Parathyroid Glands / pathology
  • Parathyroid Glands / physiopathology*