Substantial evidence supports an important role for the excitatory neurotransmitter L-glutamate as a modulator of dopamine release in the central nervous system. All of the established glutamate receptor subtypes identified to date have been implicated in the regulation of dopamine release. It appears that glutamate can exert both facilitatory and inhibitory control over dopamine release and that this may be both phasic and tonic in nature. This regulatory role suggests that drugs acting at glutamate receptors may be potentially useful therapeutic agents in neurological disorders such as parkinsonism and schizophrenia.