Viral RNA Export

Chem Biol. 1997 May;4(5):335-44. doi: 10.1016/s1074-5521(97)90124-1.

Abstract

Viruses can express intron-containing and intronless mRNAs, which are exported by alternative pathways. The study of the nuclear export of these unconventional mRNAs can provide key insights into the normal process of nuclear export and the alternative pathways provide an attractive target for the development of specific antiviral therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antiviral Agents / pharmacology
  • Biological Transport
  • Cell Nucleus / metabolism
  • Gene Products, rev / metabolism
  • HIV-1 / chemistry
  • Humans
  • Introns
  • Molecular Sequence Data
  • Molecular Structure
  • Protein Sorting Signals / chemistry
  • Proteins / metabolism
  • RNA, Messenger / metabolism
  • RNA, Viral / metabolism*
  • Viral Proteins / metabolism
  • rev Gene Products, Human Immunodeficiency Virus

Substances

  • Antiviral Agents
  • Gene Products, rev
  • Protein Sorting Signals
  • Proteins
  • RNA, Messenger
  • RNA, Viral
  • Viral Proteins
  • rev Gene Products, Human Immunodeficiency Virus