Adjuvant therapy with hydrolytic enzymes in recurrent laryngeal papillomatosis

Acta Otolaryngol Suppl. 1997;527:128-30. doi: 10.3109/00016489709124054.


The subject of this study is systemic enzymotherapy as adjuvant treatment in recurrent laryngeal papillomatosis. The authors analyze their observations of 5 adult patients with recurrent laryngeal papillomatosis when after surgical extirpation and subsequent application of peroral proteases there was a significant improvement of their clinical state and laboratory results. The patients have been disease-free from 10 to 18 months. In the authors' experience, the adjuvant enzymotherapy seems to be a suitable replacement of the supplementary treatment in larynx papillomatosis, and it promises to decrease the recurrence rate as well.

Publication types

  • Case Reports

MeSH terms

  • Adjuvants, Immunologic / therapeutic use*
  • Adult
  • Aged
  • Drug Combinations
  • Humans
  • Hydrolases / therapeutic use*
  • Laryngeal Neoplasms / drug therapy*
  • Laryngeal Neoplasms / surgery
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy*
  • Papilloma / drug therapy*
  • Papilloma / surgery
  • Rutin / therapeutic use*


  • Adjuvants, Immunologic
  • Drug Combinations
  • Rutin
  • Wobenzym
  • Hydrolases