Disorders of hemostasis in childhood: risk factors for venous thromboembolism

Thromb Haemost. 1997 Jul;78(1):710-4.


In both children and neonates with venous thrombosis, one or more predisposing risk factors can generally be identified. Underlying prothrombotic medical conditions are common in these patients. In addition, a "trigger factor" such as a catheter, surgery or trauma is usually present. However genetic and acquired coagulation abnormalities are also identified in children with venous thrombosis who are appropriately studied. A careful family history and assays for the LA, AT-III, protein C, protein S and the factor V Leiden mutation should be part of the evaluation of infants and children with venous thrombosis.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Catheterization, Central Venous / adverse effects
  • Child
  • Child, Preschool
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • Clinical Trials as Topic
  • Female
  • Hemostasis / physiology*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Postoperative Complications
  • Risk Factors
  • Thromboembolism / epidemiology
  • Thromboembolism / genetics
  • Thromboembolism / physiopathology*
  • Thrombophlebitis / epidemiology
  • Thrombophlebitis / genetics
  • Thrombophlebitis / physiopathology*